IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension

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Observations on hypoxic pulmonary hypertension.

The increase in pulmonary arterial pressure that occurs when low concentrations of oxygen are inspired (von Euler and Liljestrand, 1946) is associated with a fall in pulmonary artery oxygen saturation, and results from an increase in pulmonary arteriolar resistance (Motley et al., 1947; Lewis and Gorlin, 1952). Experiments on isolated perfused lungs in cat and dog (Hall, 1953; Duke, 1954, 1957)...

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ژورنال

عنوان ژورنال: EBioMedicine

سال: 2018

ISSN: 2352-3964

DOI: 10.1016/j.ebiom.2018.07.004